Association between copper excess, zinc deficiency, and TP53 mutations in esophageal squamous cell carcinoma from Kashmir Valley, India–a high risk area

Abstract:
Trace element deficiency or excess is implicated in the development or progression in some cancers. Here we report the elevated level of copper and low level of zinc in the plasma of esophageal cancer patients in Kashmir India–a high incidence area. The average level of copper was significantly higher (P < 0.0001) for patients [...]

By |October 16th, 2015|Research|0 Comments

Copper excess, zinc deficiency, and cognition loss in Alzheimer’s disease

Abstract:
In this special issue about biofactors causing cognitive impairment, we present evidence for and discuss two such biofactors. One is excess copper, causing neuronal toxicity. The other is zinc deficiency, causing neuronal damage. We present evidence that Alzheimer’s disease (AD) has become an epidemic in developed, but not undeveloped, countries and that the epidemic […]

By |October 16th, 2015|Research|0 Comments

Protective role of copper, zinc superoxide dismutase against UVB-induced injury of the human keratinocyte cell line HaCaT

Abstract:
On the basis of our recent observation that copper, zinc-superoxide dismutase and manganese-superoxide dismutase change differently following a single exposure to ultraviolet-B irradiation in the human keratinocyte cell line HaCaT, we have examined the possible role of endogenous copper,zinc-superoxide dismutase or manganese-superoxide dismutase against ultraviolet-B-induced reactive-oxygen- species-mediated keratinocyte injury in vitro. To evaluate the […]

By |October 14th, 2015|Research|0 Comments

Zinc deficiency induces dysregulation of cytokine productions in an experimental colitis of rats

Abstract:
Dextran sulfate sodium (DSS)-induced colitis is an experimental model of ulcerative colitis, although the precise mechanism has not yet been elucidated. We investigate whether Zn deficiency affects the pathogenesis of colitis induced by DSS with a focus on immune responses. Male WKAH/Hkm Slc rats were fed either a Zn-adequate (ZA, 30 mg Zn/kg diet) […]

By |October 14th, 2015|Research|0 Comments

Zinc sulphate solution enema decreases inflammation in experimental colitis in rats

Abstract:
BACKGROUND: It has been reported that zinc sulphate contributes an anti-inflammatory action in many animal models; however, the impact of zinc in colitis remains unclear. The aim of the present study was to examine the role of zinc sulphate in experimental colitis.METHODS: Colitis was induced by 2,4,6-trinitrobenzenesulphonic acid (TNB) in rats. Beginning at the […]

By |October 14th, 2015|Research|0 Comments

Effect of zinc supplementation on intestinal permeability in experimental colitis

Abstract:
Increased small-intestine permeability has been documented in experimental colitis in the rat. Zinc supplementation improves mucosal repair in patients with diarrhea, as well as paracellular permeability in malnourished guinea pigs. In this study, we sought to evaluate the effect of zinc supplementation on small-and large-intestine tight junctions in rats with acute colitis. Rats were […]

By |October 14th, 2015|Research|0 Comments

Innovative uses for zinc in dermatology

Abstract:
Severe zinc deficiency states, such as acrodermatitis enteropathica, are associated with a variety of skin manifestations, such as perioral, acral, and perineal dermatitis. These syndromes can be reversed with systemic zinc repletion. In addition to skin pathologies that are clearly zinc-dependent, many dermatologic conditions (eg, dandruff, acne, and diaper rash) have been associated and […]

By |October 14th, 2015|Research|0 Comments

Hidradenitis suppurativa and zinc: a new therapeutic approach. A pilot study

Abstract:
BACKGROUND: Hidradenitis suppurativa (Verneuil’s disease) is a chronic suppurative dermatosis involving apocrine glands with a severe impact on the quality of life, which is enhanced by the fact that the drugs usually prescribed are poorly effective.OBJECTIVE: We discuss a new therapeutic approach based on zinc salts.METHODS: We performed a pilot study on 22 patients, […]

By |October 14th, 2015|Research|0 Comments

Hidradenitis suppurativa: the role of deficient cutaneous innate immunity

Abstract:
OBJECTIVE: To evaluate the expression of innate immunity markers at the site of nodules caused by hidradenitis suppurativa (HS).DESIGN: Prospective analysis of 12 patients with HS.SETTING: Unité de Cancéro-Dermatologie, Nantes Hospital, Nantes; Service de Dermatologie, Poitiers Hospital, Poitiers; and Service de Dermatologie, Clinique de Courlancy, Reims, FrancePATIENTS: Twelve patients (Hurley stage I or II) […]

By |October 14th, 2015|Research|0 Comments

Zinc and the skin

Abstract:
Zinc is an essential trace element integrally involved in a wide range of metabolic processes required for tissue growth and repair as well as being necessary for maintaining host defences. Zinc deficiency can occur from lack of adequate dietary intake, decreased intestinal absorption, and increased losses in the gastrointestinal tract, urine, and sweat. The […]

By |October 14th, 2015|Research|0 Comments

Evidence supporting zinc as an important antioxidant for skin

Abstract:
Antioxidants play a critical role in keeping skin healthy. The antioxidant benefits of vitamin C and E are well known, but the importance of the trace mineral, zinc, has been overlooked. This article reviews the evidence supporting zinc’s antioxidant role in protecting against free radical-induced oxidative damage. Zinc protects against UV radiation, enhances wound […]

By |October 14th, 2015|Research|0 Comments

Clinical manifestations of zinc deficiency

Abstract:
The essentiality of zinc for humans was recognized in the early 1960s. The causes of zinc deficiency include malnutrition, alcoholism, malabsorption, extensive burns, chronic debilitating disorders, chronic renal diseases, following uses of certain drugs such as penicillamine for Wilson’s disease and diuretics in some cases, and genetic disorders such as acrodermatitis enteropathica and sickle […]

By |October 14th, 2015|Research|0 Comments

Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials

Abstract:
BACKGROUND: Zinc deficiency is prevalent in children in developing countries. Supplemental zinc provides therapeutic benefits in diarrhea.OBJECTIVE: We sought to measure the effect of supplemental zinc given with oral rehydration therapy during recovery from acute or persistent diarrhea.DESIGN: We conducted pooled analyses including all available published and unpublished randomized controlled trials of the effects […]

By |October 14th, 2015|Research|0 Comments

Human zinc deficiency

Abstract:
The objective of this paper is to provide a current overview of the significance of zinc in human nutrition. To achieve this, the following issues are addressed: (1) the biochemistry and biology of zinc in the context of their relevance to zinc in human nutrition and to our understanding of the complexity and practical […]

By |October 14th, 2015|Research|0 Comments

Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study

Abstract:
A growing body of evidence implicates a derangement of zinc homeostasis in mood disorders. In general, unipolar depression is connected with low blood zinc levels that are increased by effective antidepressant therapy. A placebo-controlled, double blind pilot study of zinc supplementation in antidepressant therapy was conducted in patients who fulfilled DSM IV criteria for […]

By |October 14th, 2015|Research|0 Comments

Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress

Abstract:
BACKGROUND: Zinc deficiency, cell-mediated immune dysfunction, susceptibility to infections, and increased oxidative stress have been observed in elderly subjects (ie, those >55 y old). Zinc is an effective antiinflammatory and antioxidant agent.OBJECTIVES: The primary objective was to determine the effect of zinc on the incidence of total infections in healthy elderly subjects. The secondary […]

By |October 14th, 2015|Research|0 Comments

Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count

Abstract:
The effects of zinc therapy on plasma testosterone (T), dihydrotestosterone (DHT), and sperm count were studied in 37 patients with idiopathic infertility of more than five years duration. In the first group (T less than 4.8 ng/ml; 22 patients), T and DHT rose significantly after oral administration of zinc, as did the sperm count. […]

By |October 14th, 2015|Research|0 Comments

Impact of the discovery of human zinc deficiency on health

Abstract:
The essentiality of zinc was recognized 46 years ago. Zinc deficiency resulting in growth retardation, hypogonadism, immune dysfunction and cognitive impairment affects nearly 2 billion subjects in the developing world. High phytate content of the cereal proteins consumed in the developing world, results in decreased availability of zinc for absorption. Zinc therapy has been […]

By |October 14th, 2015|Research|0 Comments

Zinc in human health: effect of zinc on immune cells

Abstract:
Although the essentiality of zinc for plants and animals has been known for many decades, the essentiality of zinc for humans was recognized only 40 years ago in the Middle East. The zinc-deficient patients had severe immune dysfunctions, inasmuch as they died of intercurrent infections by the time they were 25 years of age. […]

By |October 14th, 2015|Research|0 Comments

Zinc deficiency

Abstract:
PURPOSE OF REVIEW: Zinc plays an essential role in numerous biochemical pathways. Zinc deficiency affects many organ systems, including the integumentary, gastrointestinal, central nervous system, immune, skeletal, and reproductive systems. This article aims to discuss zinc metabolism and highlights a few of the diseases associated with zinc deficiency.RECENT FINDINGS: Zinc deficiency results in dysfunction […]

By |October 14th, 2015|Research|0 Comments

Zinc and the immune system

Abstract:
Zn is an essential trace element for all organisms. In human subjects body growth and development is strictly dependent on Zn. The nervous, reproductive and immune systems are particularly influenced by Zn deficiency, as well as by increased levels of Zn. The relationship between Zn and the immune system is complex, since there are […]

By |October 14th, 2015|Research|0 Comments

Zinc for the common cold

Abstract:
BACKGROUND: The common cold is one of the most widespread illnesses and is a leading cause of visits to the doctor and absenteeism from school and work. Trials conducted in high-income countries since 1984 investigating the role of zinc for the common cold symptoms have had mixed results. Inadequate treatment masking and reduced bioavailability […]

By |October 14th, 2015|Research|0 Comments

Appropriate nutrient supplementation in celiac disease

Abstract:
Reduced levels of iron, folate, vitamin B12, vitamin D, zinc, and magnesium are common in untreated celiac disease (CD) patients probably due to loss of brush border proteins and enzymes needed for the absorption of these nutrients. In the majority of patients, removal of gluten from the diet leads to histological recovery and normalization […]

By |October 13th, 2015|Research|0 Comments

Zinc inhibits magnesium-dependent migration of human breast cancer MDA-MB-231 cells on fibronectin

Abstract:
Metastasis is the major cause of breast cancer mortality. The strength of cell adhesion to extracellular matrix is critical to cancer cell migration. Integrins, the primary mediators of cell to extra-cellular matrix adhesion, contain distinct divalent cation-binding sites. Binding of manganese and magnesium is vital to integrin-mediated cancer cell adhesion and migration. We hypothesized […]

By |October 13th, 2015|Research|0 Comments

Zinc involvement in opioid addiction and analgesia–should zinc supplementation be recommended for opioid-treated persons?

Abstract:
INTRODUCTION: Zinc chelators were shown to facilitate some opioid-withdrawal signs in animals. Zinc deficiency, which affects more than 15% the world’s population, is also common among opioid consumers and opioid-treated animals exhibit misbalances of zinc distribution.AIM: The present study focuses on how zinc ions interfere with opioid dependence/addiction and analgesia, trying to preliminary discuss […]

By |October 12th, 2015|Research|0 Comments