Selenium in cancer prevention: a review of the evidence and mechanism of action

Abstract:
Se is an unusual trace element in having its own codon in mRNA that specifies its insertion into selenoproteins as selenocysteine (SeCys), by means of a mechanism requiring a large SeCys-insertion complex. This exacting insertion machinery for selenoprotein production has implications for the Se requirements for cancer prevention. If Se may protect against cancer, […]

By |October 16th, 2015|Research|0 Comments

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

Abstract:
OBJECTIVE: To determine whether a nutritional supplement of selenium will decrease the incidence of cancer.DESIGN: A multicenter, double-blind, randomized, placebo-controlled cancer prevention trial.SETTING: Seven dermatology clinics in the eastern United States.PATIENTS: A total of 1312 patients (mean age, 63 years; range, 18-80 years) with a history of basal cell or squamous cell carcinomas of […]

By |October 16th, 2015|Research|0 Comments

Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the action of selenium

Abstract:
We reported previously that garlic cultivated with selenite fertilization showed powerful chemopreventive activity in the rat dimethylbenz[a]anthracene (DMBA)-induced mammary tumor model (Carcinogenesis 15, 573-576, 1994). In order to ascertain that the efficacy of the high-selenium garlic in cancer protection is primarily dependent on the action of selenium we compared the effects of two batches […]

By |October 16th, 2015|Research|0 Comments

Magnesium and cancer: a dangerous liason

Abstract:
A complex relationship links magnesium and cancer. The aim of this review is to revisit current knowledge concerning the contribution of magnesium to tumorigenesis, from transformed cells to animal models, and ending with data from human studies. Cultured neoplastic cells tend to accumulate magnesium. High intracellular levels of the cation seem to confer a […]

By |October 14th, 2015|Research|0 Comments

Magnesium intake in relation to risk of colorectal cancer in women

Abstract:
CONTEXT: Animal studies have suggested that dietary magnesium may play a role in the prevention of colorectal cancer, but data in humans are lacking.OBJECTIVE: To evaluate the hypothesis that a high magnesium intake reduces the risk of colorectal cancer in women.DESIGN, SETTING, AND PARTICIPANTS: The Swedish Mammography Cohort, a population-based prospective cohort of 61,433 […]

By |October 14th, 2015|Research|0 Comments

Magnesium deficiency inhibits primary tumor growth but favors metastasis in mice

Abstract:
The results of several experimental and epidemiological studies have shown an inverse correlation between Mg status and the risk of some cancers. However, relationship between magnesium and cancer is complex. The aim of our work was to examine the precise effect of Mg deficiency on transplantable mouse tumor growth and metastasis. The results obtained […]

By |October 14th, 2015|Research|0 Comments

Dietary magnesium intake and risk of cancer: a meta-analysis of epidemiologic studies

Abstract:
The aim of this study was to investigate the association between dietary magnesium and the risk of overall cancer using a meta-analysis. We searched PubMed, SCOPUS, and the Cochrane Review through November 2012. All the articles searched were independently reviewed by 3 authors based on predetermined selection criterion. A total of 13 epidemiologic studies, […]

By |October 14th, 2015|Research|0 Comments

Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality

Abstract:
BACKGROUND: Experimental data suggest that zinc, copper, and magnesium are involved in carcinogenesis and atherogenesis. Few longitudinal studies have related these minerals to cancer or cardiovascular disease mortality in a population.METHODS: Data from the Paris Prospective Study 2, a cohort of 4035 men age 30-60 years at baseline, were used to assess the association […]

By |October 14th, 2015|Research|0 Comments

Nonlinear association between magnesium intake and the risk of colorectal cancer

Abstract:
OBJECTIVES: The association between dietary magnesium intake and the risk of colorectal cancer has been examined by many prospective studies, but remains controversial because of inconsistent results. We aimed to carry out a meta-analysis to investigate this.MATERIALS AND METHODS: We assessed this association with categorical and dose-response meta-analysis of data from prospective cohort studies. […]

By |October 14th, 2015|Research|0 Comments

High dietary intake of magnesium may decrease risk of colorectal cancer in Japanese men

Abstract:
Magnesium maintains genomic stability and is an essential cofactor for DNA synthesis and repair. Magnesium intake has been reported to be inversely associated with colorectal cancer (CRC) risk in Western populations. This study examined the association between dietary intake of magnesium and CRC risk in Japanese men and women aged 45-74 y. Data from […]

By |October 14th, 2015|Research|0 Comments

Magnesium intake and risk of colorectal cancer: a meta-analysis of prospective studies

Abstract:
Epidemiologic studies have suggested that magnesium intake may be associated with a decreased risk of colorectal cancer (CRC), but the findings have been inconsistent. We aimed to assess this association by conducting a meta-analysis of prospective studies. We performed a literature search on PubMed database through July 2012 to identify prospective studies of magnesium […]

By |October 14th, 2015|Research|0 Comments

Effects of magnesium supplementation in testicular cancer patients receiving cis-platin: a randomised trial

Abstract:
The concentration of magnesium in serum has been shown to fall to potentially dangerously low levels after several courses of treatment with cis-diamminedichloroplatinum II (cis-platin). The aims of this study were to examine the effects of magnesium supplementation on predicted outcome of treatment, rate of response to treatment and toxicity of treatment. Sixteen patients […]

By |October 14th, 2015|Research|0 Comments

Blood magnesium, and the interaction with calcium, on the risk of high-grade prostate cancer

Abstract:
BACKGROUND: Ionized calcium (Ca) and magnesium (Mg) compete as essential messengers to regulate cell proliferation and inflammation. We hypothesized that inadequate Mg levels, perhaps relative to Ca levels (e.g. a high Ca/Mg ratio) are associated with greater prostate cancer risk.STUDY DESIGN: In this biomarker sub-study of the Nashville Men’s Health Study (NMHS), we included […]

By |October 14th, 2015|Research|0 Comments

Zinc inhibits magnesium-dependent migration of human breast cancer MDA-MB-231 cells on fibronectin

Abstract:
Metastasis is the major cause of breast cancer mortality. The strength of cell adhesion to extracellular matrix is critical to cancer cell migration. Integrins, the primary mediators of cell to extra-cellular matrix adhesion, contain distinct divalent cation-binding sites. Binding of manganese and magnesium is vital to integrin-mediated cancer cell adhesion and migration. We hypothesized […]

By |October 13th, 2015|Research|0 Comments

A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients

Abstract:
BACKGROUND: We tested if magnesium would diminish bothersome hot flashes in breast cancer patients.METHODS: Breast cancer patients with at least 14 hot flashes a week received magnesium oxide 400 mg for 4 weeks, escalating to 800 mg if needed. Hot flash score (frequency × severity) at baseline was compared to the end of treatment.RESULTS: Of 29 who enrolled, 25 […]

By |October 13th, 2015|Research|0 Comments

Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer?

Abstract:
Breast cancer is the most commonly diagnosed cancer among United States (US) women. Established risk factors explain only about 13% of breast cancer incidence among women in the US. Thus, the cause of most cases of breast cancer remains unknown. In postmenopausal women, serum calcium (Ca) and serum magnesium (Mg) play an important role […]

By |October 13th, 2015|Research|0 Comments

Serum levels of metal ions in female patients with breast cancer

Abstract:
BACKGROUND: Breast cancer is the second commonest form of cancer among women. Several studies have been conducted to identify potential risk factors. However, role of trace elements or metals in causing breast cancer has not been studied to great extent.AIMS: To estimate the serum levels of calcium, copper, magnesium, iron, phosphorus and zinc and […]

By |October 13th, 2015|Research|0 Comments