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Effects of magnesium and its mechanism on the incidence of reperfusion arrhythmias following severe ischemia in isolated rat hearts

Abstract:
Magnesium sulfate (Mg) has been widely used for the treatment of ventricular arrhythmias (VF) in patients with coronary artery disease. However, the mechanisms of prevention on the incidence of VF have not been defined. The aim of study was to investigate the role of Mg in the prevention of VF and the mechanism of […]

By |October 18th, 2015|Research|0 Comments

Magnesium supplementation in the prevention of arrhythmias in pediatric patients undergoing surgery for congenital heart defects

Abstract:
BACKGROUND: The efficacy of magnesium in the prevention of arrhythmias in pediatric patients after heart surgery remains unknown. Therefore we prospectively examined the effect of magnesium treatment on the incidence of postoperative arrhythmias in pediatric patients undergoing surgical repair of congenital heart defects.METHODS AND RESULTS: Twenty-eight pediatric patients undergoing heart surgery with cardiopulmonary bypass […]

By |October 18th, 2015|Research|0 Comments

[Magnesium and arrhythmia]

Abstract:
Experimental and clinical studies have shown the antiarrhythmic activity of magnesium salts and the arrhythmogenic effect of hypomagnesemia. Both are observed mainly but not exclusively during treatment with digitalis. The Mg++ plays an essential role in transmembrane K+ exchange in that a deficit of magnesium leads to a loss of intracellular K+ which cannot […]

By |October 18th, 2015|Research|0 Comments

Magnesium treatment of ventricular arrhythmias

Abstract:
The association between marked hypomagnesemia and arrhythmias, particularly those associated with digitalis intoxication, has long been recognized. More recently, acute intervention with magnesium in patients who are not hypomagnesemic has demonstrated arrhythmia suppression in 3 settings: digitalis intoxication, long QT-related arrhythmias and arrhythmias after acute myocardial infarction. Although the electrophysiologic effects of magnesium are […]

By |October 18th, 2015|Research|0 Comments

Effect of acute magnesium administration on the frequency of ventricular arrhythmia in patients with heart failure

Summary:
Giving magnesium to patients with heart failure reduces the frequency of their arrhythmias.

Abstract:
BACKGROUND: There is a high incidence of ventricular arrhythmia and sudden death in patients with heart failure. Unfortunately, currently available antiarrhythmic agents have only limited efficacy and may result in proarrhythmia and hemodynamic deterioration in these patients.METHODS AND RESULTS: We studied […]

By |October 18th, 2015|Research|0 Comments

Magnesium therapy of cardiac arrhythmias in critical-care medicine

Abstract:
A common complication of critically ill patients is cardiac tachyarrhythmia. The role played by magnesium is not well appreciated. Well-documented cases indicated that magnesium may be effective in controlling the rhythm when conventional methods fail. The following tachyarrhythmias respond favorably to magnesium: (1) intractable ventricular tachycardia and fibrillation, whether hypo- or normomagnesemic, (2) torsades […]

By |October 18th, 2015|Research|0 Comments

Intravenous magnesium for cardiac arrhythmias: jack of all trades

Abstract:
Intravenous magnesium has been used to prevent and treat many different types of cardiac arrhythmia. It has diverse electrophysiological actions on the conduction system of the heart; including prolonging sinus node recovery time, and reducing automaticity, atrioventricular nodal conduction, antegrade and retrograde conduction over an accessory pathway, and His-ventricular conduction. Intravenous magnesium can also […]

By |October 18th, 2015|Research|0 Comments

[Significance of magnesium in cardiac arrhythmias]

Abstract:
Magnesium is of great importance in cardiac arrhythmias. It increases the ventricular threshold for fibrillation. Sinus node refractoriness and conduction in the AV node are both prolonged. Main indications for intravenous application of magnesium are Torsade de pointes tachycardias, digitalis toxicity induced tachyarrhythmias and multifocal atrial tachycardias. Additionally, patients with ventricular arrhythmias due to […]

By |October 18th, 2015|Research|0 Comments

Strontium nitrate suppresses chemically-induced sensory irritation in humans

Summary:
Strontium salts strongly reduces stinging, burning, and itching caused by irritating chemicals on the skin.

Abstract:
Skin care products are complex formulations that may cause sensory irritation symptoms, characterized by stinging, burning, and itching. Substances capable of counteracting sensory irritation are of great practical interest. Strontium salts have been demonstrated to inhibit sensory irritation […]

By |October 16th, 2015|Research|0 Comments

Strontium is a potent and selective inhibitor of sensory irritation

Summary:
Strontium salts strongly reduced skin irritation without side-effects, representing a new class of topical anti-inflammatories.

Abstract:
BACKGROUND: Irritant contact dermatitis occurs following topical exposure to many chemicals found in cosmetics, personal care products, drugs, and during occupational exposure. Signs and symptoms may include sensory irritation (sting, burn, and/or itch), erythema, edema, and vesiculation.OBJECTIVE: In […]

By |October 16th, 2015|Research|0 Comments

Strontium chloride: can it be a new treatment option for ulcerative colitis?

Summary:
Strontium salts are as effective as prednisone for treating ulcerative colitis, but without the side-effects!

Abstract:
BACKGROUND/AIMS: Patients with ulcerative colitis still need effective therapy without major side effects. It has been found that strontium can suppress NFκB activation induced by TNF-α. This opens a gate to a new anti-TNF agent which is cheap […]

By |October 16th, 2015|Research|0 Comments

Efficacy of strontium chloride in dental hypersensitivity

Abstract:
Controlled stimuli were used to evaluate a commercially available dentifrice containing 10% strontium chloride hexahydrate for efficacy in alleviating the symptoms of uncomplicated dentinal hypersensitivity. Sixty-one subjects with hypersensitivity were included in the 12-week, double-blind, parallel, comparative (placebo) study. Levels of hypersensitivity in affected teeth were assessed by three methods: thermally controlled cold air […]

By |October 16th, 2015|Research|0 Comments

Controlled clinical evaluation of a 10% strontium chloride dentifrice in treatment of dentin hypersensitivity following periodontal surgery

Abstract:
Sixty adult patients were examined for dentin hypersensitivity prior to periodontal surgery. Stimuli used included mechanical, cold water and compressed air blasts. A subjective assessment of the degree of hypersensitivity for each stimulus was recorded. This presurgical examination revealed 249 hypersensitive areas among 60 subjects. Following surgery there was over a 100% increase in […]

By |October 16th, 2015|Research|0 Comments

Association between copper excess, zinc deficiency, and TP53 mutations in esophageal squamous cell carcinoma from Kashmir Valley, India–a high risk area

Abstract:
Trace element deficiency or excess is implicated in the development or progression in some cancers. Here we report the elevated level of copper and low level of zinc in the plasma of esophageal cancer patients in Kashmir India–a high incidence area. The average level of copper was significantly higher (P < 0.0001) for patients [...]

By |October 16th, 2015|Research|0 Comments

Copper excess, zinc deficiency, and cognition loss in Alzheimer’s disease

Abstract:
In this special issue about biofactors causing cognitive impairment, we present evidence for and discuss two such biofactors. One is excess copper, causing neuronal toxicity. The other is zinc deficiency, causing neuronal damage. We present evidence that Alzheimer’s disease (AD) has become an epidemic in developed, but not undeveloped, countries and that the epidemic […]

By |October 16th, 2015|Research|0 Comments

Selenium in cancer prevention: a review of the evidence and mechanism of action

Abstract:
Se is an unusual trace element in having its own codon in mRNA that specifies its insertion into selenoproteins as selenocysteine (SeCys), by means of a mechanism requiring a large SeCys-insertion complex. This exacting insertion machinery for selenoprotein production has implications for the Se requirements for cancer prevention. If Se may protect against cancer, […]

By |October 16th, 2015|Research|0 Comments

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

Abstract:
OBJECTIVE: To determine whether a nutritional supplement of selenium will decrease the incidence of cancer.DESIGN: A multicenter, double-blind, randomized, placebo-controlled cancer prevention trial.SETTING: Seven dermatology clinics in the eastern United States.PATIENTS: A total of 1312 patients (mean age, 63 years; range, 18-80 years) with a history of basal cell or squamous cell carcinomas of […]

By |October 16th, 2015|Research|0 Comments

Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the action of selenium

Abstract:
We reported previously that garlic cultivated with selenite fertilization showed powerful chemopreventive activity in the rat dimethylbenz[a]anthracene (DMBA)-induced mammary tumor model (Carcinogenesis 15, 573-576, 1994). In order to ascertain that the efficacy of the high-selenium garlic in cancer protection is primarily dependent on the action of selenium we compared the effects of two batches […]

By |October 16th, 2015|Research|0 Comments

Protective role of copper, zinc superoxide dismutase against UVB-induced injury of the human keratinocyte cell line HaCaT

Abstract:
On the basis of our recent observation that copper, zinc-superoxide dismutase and manganese-superoxide dismutase change differently following a single exposure to ultraviolet-B irradiation in the human keratinocyte cell line HaCaT, we have examined the possible role of endogenous copper,zinc-superoxide dismutase or manganese-superoxide dismutase against ultraviolet-B-induced reactive-oxygen- species-mediated keratinocyte injury in vitro. To evaluate the […]

By |October 14th, 2015|Research|0 Comments

Copper in diseases and treatments, and copper-based anticancer strategies

Abstract:
Copper is found in all living organisms and is a crucial trace element in redox chemistry, growth and development. It is important for the function of several enzymes and proteins involved in energy metabolism, respiration, and DNA synthesis, notably cytochrome oxidase, superoxide dismutase, ascorbate oxidase, and tyrosinase. The major functions of copper-biological molecules involve […]

By |October 14th, 2015|Research|0 Comments

Zinc deficiency induces dysregulation of cytokine productions in an experimental colitis of rats

Abstract:
Dextran sulfate sodium (DSS)-induced colitis is an experimental model of ulcerative colitis, although the precise mechanism has not yet been elucidated. We investigate whether Zn deficiency affects the pathogenesis of colitis induced by DSS with a focus on immune responses. Male WKAH/Hkm Slc rats were fed either a Zn-adequate (ZA, 30 mg Zn/kg diet) […]

By |October 14th, 2015|Research|0 Comments

Zinc sulphate solution enema decreases inflammation in experimental colitis in rats

Abstract:
BACKGROUND: It has been reported that zinc sulphate contributes an anti-inflammatory action in many animal models; however, the impact of zinc in colitis remains unclear. The aim of the present study was to examine the role of zinc sulphate in experimental colitis.METHODS: Colitis was induced by 2,4,6-trinitrobenzenesulphonic acid (TNB) in rats. Beginning at the […]

By |October 14th, 2015|Research|0 Comments

Effect of zinc supplementation on intestinal permeability in experimental colitis

Abstract:
Increased small-intestine permeability has been documented in experimental colitis in the rat. Zinc supplementation improves mucosal repair in patients with diarrhea, as well as paracellular permeability in malnourished guinea pigs. In this study, we sought to evaluate the effect of zinc supplementation on small-and large-intestine tight junctions in rats with acute colitis. Rats were […]

By |October 14th, 2015|Research|0 Comments

Hidradenitis suppurativa: the role of deficient cutaneous innate immunity

Abstract:
OBJECTIVE: To evaluate the expression of innate immunity markers at the site of nodules caused by hidradenitis suppurativa (HS).DESIGN: Prospective analysis of 12 patients with HS.SETTING: Unité de Cancéro-Dermatologie, Nantes Hospital, Nantes; Service de Dermatologie, Poitiers Hospital, Poitiers; and Service de Dermatologie, Clinique de Courlancy, Reims, FrancePATIENTS: Twelve patients (Hurley stage I or II) […]

By |October 14th, 2015|Research|0 Comments

Hidradenitis suppurativa and zinc: a new therapeutic approach. A pilot study

Abstract:
BACKGROUND: Hidradenitis suppurativa (Verneuil’s disease) is a chronic suppurative dermatosis involving apocrine glands with a severe impact on the quality of life, which is enhanced by the fact that the drugs usually prescribed are poorly effective.OBJECTIVE: We discuss a new therapeutic approach based on zinc salts.METHODS: We performed a pilot study on 22 patients, […]

By |October 14th, 2015|Research|0 Comments

Innovative uses for zinc in dermatology

Abstract:
Severe zinc deficiency states, such as acrodermatitis enteropathica, are associated with a variety of skin manifestations, such as perioral, acral, and perineal dermatitis. These syndromes can be reversed with systemic zinc repletion. In addition to skin pathologies that are clearly zinc-dependent, many dermatologic conditions (eg, dandruff, acne, and diaper rash) have been associated and […]

By |October 14th, 2015|Research|0 Comments

Evidence supporting zinc as an important antioxidant for skin

Abstract:
Antioxidants play a critical role in keeping skin healthy. The antioxidant benefits of vitamin C and E are well known, but the importance of the trace mineral, zinc, has been overlooked. This article reviews the evidence supporting zinc’s antioxidant role in protecting against free radical-induced oxidative damage. Zinc protects against UV radiation, enhances wound […]

By |October 14th, 2015|Research|0 Comments

Zinc and the skin

Abstract:
Zinc is an essential trace element integrally involved in a wide range of metabolic processes required for tissue growth and repair as well as being necessary for maintaining host defences. Zinc deficiency can occur from lack of adequate dietary intake, decreased intestinal absorption, and increased losses in the gastrointestinal tract, urine, and sweat. The […]

By |October 14th, 2015|Research|0 Comments

Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials

Abstract:
BACKGROUND: Zinc deficiency is prevalent in children in developing countries. Supplemental zinc provides therapeutic benefits in diarrhea.OBJECTIVE: We sought to measure the effect of supplemental zinc given with oral rehydration therapy during recovery from acute or persistent diarrhea.DESIGN: We conducted pooled analyses including all available published and unpublished randomized controlled trials of the effects […]

By |October 14th, 2015|Research|0 Comments

Clinical manifestations of zinc deficiency

Abstract:
The essentiality of zinc for humans was recognized in the early 1960s. The causes of zinc deficiency include malnutrition, alcoholism, malabsorption, extensive burns, chronic debilitating disorders, chronic renal diseases, following uses of certain drugs such as penicillamine for Wilson’s disease and diuretics in some cases, and genetic disorders such as acrodermatitis enteropathica and sickle […]

By |October 14th, 2015|Research|0 Comments

Human zinc deficiency

Abstract:
The objective of this paper is to provide a current overview of the significance of zinc in human nutrition. To achieve this, the following issues are addressed: (1) the biochemistry and biology of zinc in the context of their relevance to zinc in human nutrition and to our understanding of the complexity and practical […]

By |October 14th, 2015|Research|0 Comments

Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study

Abstract:
A growing body of evidence implicates a derangement of zinc homeostasis in mood disorders. In general, unipolar depression is connected with low blood zinc levels that are increased by effective antidepressant therapy. A placebo-controlled, double blind pilot study of zinc supplementation in antidepressant therapy was conducted in patients who fulfilled DSM IV criteria for […]

By |October 14th, 2015|Research|0 Comments

Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress

Abstract:
BACKGROUND: Zinc deficiency, cell-mediated immune dysfunction, susceptibility to infections, and increased oxidative stress have been observed in elderly subjects (ie, those >55 y old). Zinc is an effective antiinflammatory and antioxidant agent.OBJECTIVES: The primary objective was to determine the effect of zinc on the incidence of total infections in healthy elderly subjects. The secondary […]

By |October 14th, 2015|Research|0 Comments

Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count

Abstract:
The effects of zinc therapy on plasma testosterone (T), dihydrotestosterone (DHT), and sperm count were studied in 37 patients with idiopathic infertility of more than five years duration. In the first group (T less than 4.8 ng/ml; 22 patients), T and DHT rose significantly after oral administration of zinc, as did the sperm count. […]

By |October 14th, 2015|Research|0 Comments

Impact of the discovery of human zinc deficiency on health

Abstract:
The essentiality of zinc was recognized 46 years ago. Zinc deficiency resulting in growth retardation, hypogonadism, immune dysfunction and cognitive impairment affects nearly 2 billion subjects in the developing world. High phytate content of the cereal proteins consumed in the developing world, results in decreased availability of zinc for absorption. Zinc therapy has been […]

By |October 14th, 2015|Research|0 Comments

Zinc deficiency

Abstract:
PURPOSE OF REVIEW: Zinc plays an essential role in numerous biochemical pathways. Zinc deficiency affects many organ systems, including the integumentary, gastrointestinal, central nervous system, immune, skeletal, and reproductive systems. This article aims to discuss zinc metabolism and highlights a few of the diseases associated with zinc deficiency.RECENT FINDINGS: Zinc deficiency results in dysfunction […]

By |October 14th, 2015|Research|0 Comments

Zinc in human health: effect of zinc on immune cells

Abstract:
Although the essentiality of zinc for plants and animals has been known for many decades, the essentiality of zinc for humans was recognized only 40 years ago in the Middle East. The zinc-deficient patients had severe immune dysfunctions, inasmuch as they died of intercurrent infections by the time they were 25 years of age. […]

By |October 14th, 2015|Research|0 Comments

Zinc and the immune system

Abstract:
Zn is an essential trace element for all organisms. In human subjects body growth and development is strictly dependent on Zn. The nervous, reproductive and immune systems are particularly influenced by Zn deficiency, as well as by increased levels of Zn. The relationship between Zn and the immune system is complex, since there are […]

By |October 14th, 2015|Research|0 Comments

Zinc for the common cold

Abstract:
BACKGROUND: The common cold is one of the most widespread illnesses and is a leading cause of visits to the doctor and absenteeism from school and work. Trials conducted in high-income countries since 1984 investigating the role of zinc for the common cold symptoms have had mixed results. Inadequate treatment masking and reduced bioavailability […]

By |October 14th, 2015|Research|0 Comments

Calcium and osteoporosis

Abstract:
Calcium is an essential nutrient that is involved in most metabolic processes and the phosphate salts of which provide mechanical rigidity to the bones and teeth, where 99% of the body’s calcium resides. The calcium in the skeleton has the additional role of acting as a reserve supply of calcium to meet the body’s […]

By |October 14th, 2015|Research|0 Comments

Calcium, dairy products and osteoporosis

Abstract:
Osteoporosis is a multifactorial disorder in which nutrition plays a role but does not account for the totality of the problem. 139 papers published since 1975 and describing studies of the relationship of calcium intake and bone health are briefly analyzed. Of 52 investigator-controlled calcium intervention studies, all but two showed better bone balance […]

By |October 14th, 2015|Research|0 Comments

The relationship of dietary and supplemental calcium intake to bone loss and osteoporosis

Abstract:
Calcium supplements have become big business in the United States. The sale of calcium supplements increased sevenfold from 1980 to 1985, with +130,000,000 being spent on calcium supplements during 1985. The median daily dietary calcium intake for women in the United States is 574 mg and for men is 826 mg. The average American […]

By |October 14th, 2015|Research|0 Comments

What is the real story on taking calcium supplements? On the one hand, we’re urged to get 1,200 mg of calcium daily for bone health, and on the other, we’re told that calcium supplements appear to raise risk of heart attack and other cardiovascular events. Which is correct?

Abstract:

Duke Med Health News 2011 Jul;17(7):8
PMID: 21789813

By |October 14th, 2015|Research|0 Comments

Calcium supplements and heart attack. Opposing studies sound a note of caution on too much calcium

Abstract:

Harv Heart Lett 2010 Nov;21(3):1-2
PMID: 21162172

By |October 14th, 2015|Research|0 Comments

Calcium: Too Much of a Good Thing?

Case Report
A 60-year-old Caucasian female with a history of hypertension, anxiety, depression, and osteopenia presents for her periodic health examination. Current medications include metoprolol, venlafaxine, and a multivitamin (contains 220 mg calcium). She takes calcium citrate with vitamin D (2 tablets=500 mg elemental calcium and 800 IU vitamin D), 6 tablets daily. Her total daily dose of […]

By |October 14th, 2015|Uncategorized|0 Comments

Calcium in Alzheimer’s disease pathogenesis: too much, too little or in the wrong place?

Abstract:
Our understanding of the molecular genetics and biochemical pathology of Alzheimer’s disease has progressed tremendously in the past decade. The metabolism of amyloid beta-peptide is being unraveled, and specific anti-amyloid therapies are now in clinical trials worldwide. The precise biophysical structure of the amyloid beta-peptide that causes neuronal dysfunction remains under investigation, as does […]

By |October 14th, 2015|Research|0 Comments

Risk of high dietary calcium for arterial calcification in older adults

Abstract:
Concern has recently arisen about the potential adverse effects of excessive calcium intakes, i.e., calcium loading from supplements, on arterial calcification and risks of cardiovascular diseases (CVD) in older adults. Published reports that high calcium intakes in free-living adults have relatively little or no beneficial impact on bone mineral density (BMD) and fracture rates […]

By |October 14th, 2015|Research|0 Comments

Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices

Abstract:
The effect of low extracellular Mg2+ concentration ([Mg2+]o) on neuronal activity was studied in rat hippocampal slices. After 20-40 min of perfusion with Mg2+-free medium, when [Mg2+]o declined to approximately 0.1-0.4 mM, spontaneous field potentials developed in the CA1 and CA3 regions, but not in the dentate gyrus. In the CA3 pyramidal cell layer, […]

By |October 14th, 2015|Research|0 Comments

Anticonvulsant effects of magnesium sulfate on hippocampal seizures: therapeutic implications in preeclampsia-eclampsia

Abstract:
OBJECTIVE: The objective of this study was to determine whether magnesium sulfate has central anticonvulsant effects.STUDY DESIGN: In three experiments we investigated the anticonvulsant properties of magnesium sulfate on the hippocampus because of its high density of N-methyl-D-aspartate receptors and link to clinical epilepsy. Seizure activity was elicited in the hippocampus of rats or […]

By |October 14th, 2015|Research|0 Comments

Effect of magnesium chloride and magnesium L-aspartate on seizure threshold in rats under conditions of dietary magnesium deficiency

Abstract:
We studied the effect of Mg-L-aspartate, MgCL2, and their combinations with vitamin B6, magneB6, and MgSO4 on seizure threshold in rats with dietary Mg2+ deficiency. Mg2+ deficiency was followed by a decrease in the threshold dose of corazol (from 79.20 to 49.48 mg/kg), shortening of the latency of the first jerk (by 33.6%, p=0.012), […]

By |October 14th, 2015|Research|0 Comments