Strontium chloride: can it be a new treatment option for ulcerative colitis?

Summary:
Strontium salts are as effective as prednisone for treating ulcerative colitis, but without the side-effects!

Abstract:
BACKGROUND/AIMS: Patients with ulcerative colitis still need effective therapy without major side effects. It has been found that strontium can suppress NFκB activation induced by TNF-α. This opens a gate to a new anti-TNF agent which is cheap […]

By |October 16th, 2015|Research|1 Comment

Zinc deficiency induces dysregulation of cytokine productions in an experimental colitis of rats

Abstract:
Dextran sulfate sodium (DSS)-induced colitis is an experimental model of ulcerative colitis, although the precise mechanism has not yet been elucidated. We investigate whether Zn deficiency affects the pathogenesis of colitis induced by DSS with a focus on immune responses. Male WKAH/Hkm Slc rats were fed either a Zn-adequate (ZA, 30 mg Zn/kg diet) […]

By |October 14th, 2015|Research|0 Comments

Zinc sulphate solution enema decreases inflammation in experimental colitis in rats

Abstract:
BACKGROUND: It has been reported that zinc sulphate contributes an anti-inflammatory action in many animal models; however, the impact of zinc in colitis remains unclear. The aim of the present study was to examine the role of zinc sulphate in experimental colitis.METHODS: Colitis was induced by 2,4,6-trinitrobenzenesulphonic acid (TNB) in rats. Beginning at the […]

By |October 14th, 2015|Research|0 Comments

Effect of zinc supplementation on intestinal permeability in experimental colitis

Abstract:
Increased small-intestine permeability has been documented in experimental colitis in the rat. Zinc supplementation improves mucosal repair in patients with diarrhea, as well as paracellular permeability in malnourished guinea pigs. In this study, we sought to evaluate the effect of zinc supplementation on small-and large-intestine tight junctions in rats with acute colitis. Rats were […]

By |October 14th, 2015|Research|0 Comments