Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

Abstract:
OBJECTIVE: To determine whether a nutritional supplement of selenium will decrease the incidence of cancer.DESIGN: A multicenter, double-blind, randomized, placebo-controlled cancer prevention trial.SETTING: Seven dermatology clinics in the eastern United States.PATIENTS: A total of 1312 patients (mean age, 63 years; range, 18-80 years) with a history of basal cell or squamous cell carcinomas of […]

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Selenium in cancer prevention: a review of the evidence and mechanism of action

Abstract:
Se is an unusual trace element in having its own codon in mRNA that specifies its insertion into selenoproteins as selenocysteine (SeCys), by means of a mechanism requiring a large SeCys-insertion complex. This exacting insertion machinery for selenoprotein production has implications for the Se requirements for cancer prevention. If Se may protect against cancer, […]

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Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the action of selenium

Abstract:
We reported previously that garlic cultivated with selenite fertilization showed powerful chemopreventive activity in the rat dimethylbenz[a]anthracene (DMBA)-induced mammary tumor model (Carcinogenesis 15, 573-576, 1994). In order to ascertain that the efficacy of the high-selenium garlic in cancer protection is primarily dependent on the action of selenium we compared the effects of two batches […]

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