Strontium chloride: can it be a new treatment option for ulcerative colitis?

Summary:
Strontium salts are as effective as prednisone for treating ulcerative colitis, but without the side-effects!

Abstract:
BACKGROUND/AIMS: Patients with ulcerative colitis still need effective therapy without major side effects. It has been found that strontium can suppress NFκB activation induced by TNF-α. This opens a gate to a new anti-TNF agent which is cheap […]

By |October 16th, 2015|Research|1 Comment

Zinc deficiency induces dysregulation of cytokine productions in an experimental colitis of rats

Abstract:
Dextran sulfate sodium (DSS)-induced colitis is an experimental model of ulcerative colitis, although the precise mechanism has not yet been elucidated. We investigate whether Zn deficiency affects the pathogenesis of colitis induced by DSS with a focus on immune responses. Male WKAH/Hkm Slc rats were fed either a Zn-adequate (ZA, 30 mg Zn/kg diet) […]

By |October 14th, 2015|Research|0 Comments

Zinc sulphate solution enema decreases inflammation in experimental colitis in rats

Abstract:
BACKGROUND: It has been reported that zinc sulphate contributes an anti-inflammatory action in many animal models; however, the impact of zinc in colitis remains unclear. The aim of the present study was to examine the role of zinc sulphate in experimental colitis.METHODS: Colitis was induced by 2,4,6-trinitrobenzenesulphonic acid (TNB) in rats. Beginning at the […]

By |October 14th, 2015|Research|0 Comments

Effect of zinc supplementation on intestinal permeability in experimental colitis

Abstract:
Increased small-intestine permeability has been documented in experimental colitis in the rat. Zinc supplementation improves mucosal repair in patients with diarrhea, as well as paracellular permeability in malnourished guinea pigs. In this study, we sought to evaluate the effect of zinc supplementation on small-and large-intestine tight junctions in rats with acute colitis. Rats were […]

By |October 14th, 2015|Research|0 Comments

Plasma and skeletal muscle electrolytes in patients with Crohn’s disease

Abstract:
Plasma and skeletal muscle electrolytes were measured in 13 patients with Crohn’s disease, and in an age- and sex-matched reference group. Patients with Crohn’s disease demonstrated significantly lower muscle potassium content (p less than 0.01) than did controls. Patients with extensive involvement of the bowel tended to have lower muscle potassium content. The patient […]

By |October 14th, 2015|Research|0 Comments

Hypocalcemia secondary to hypomagnesemia in a patient with Crohn’s disease

Abstract:
A 42-year-old female with Crohn’s disease who had previously undergone multiple surgical interventions developed marked hypocalcemia, which could not be resolved with calcium administration. Markedly reduced serum magnesium levels were also observed. After intravenous magnesium administration, serum calcium levels rapidly normalized. In addition, the plasma levels of intact parathyroid hormone increased immediately after magnesium […]

By |October 14th, 2015|Research|0 Comments

Objectively measured muscle fatigue in Crohn’s disease: correlation with self-reported fatigue and associated factors for clinical application

Abstract:
BACKGROUND & AIMS: The association of fatigue with decreased physical performance and underlying mechanisms are poorly understood in Crohn’s disease (CD). We aimed to measure and compare self-reported fatigue with skeletal muscle fatigue in CD subjects and healthy controls, and to identify associated factors that may be amenable to change.METHODS: Demographic and clinical data […]

By |October 14th, 2015|Research|0 Comments

[Patient with Crohn’s disease and seizures due to hypomagnesemia]

Abstract:
We report a patient with Crohn’s disease who suffered several generalized convulsions. He was studied with cerebral image techniques and neurophysiologic tests without getting the aetiology of the convulsions. A severe depletion in magnesium levels was suspected at the time of the initial evaluation by the Nutritional Team Group. Low serum magnesium levels were […]

By |October 14th, 2015|Research|0 Comments

Magnesium deficiency after ileal resections for Crohn’s disease

Abstract:
The magnesium status of the body was studied in 87 patients with various lengths of small-bowel resections for Crohn’s disease. The urinary magnesium excretion decreased with increasing resection length, and so did the concentration of magnesium in muscle. Muscular fatigue, an early symptom of magnesium deficiency, was positively correlated to a pathologically low concentration […]

By |October 14th, 2015|Research|0 Comments

Domino effect of hypomagnesemia on the innate immunity of Crohn’s disease patients

Abstract:
Digestive diseases play major role in development and complications of other disorders including diabetes. For example, Crohn’s disease (CD) is an inflammatory bowel disease associated with Mycobacterium avium subspecies paratuberculosis. The inflammation is a complex process that involves the activity of both innate and adaptive immune responses. CD lesions are primarily due to T […]

By |October 14th, 2015|Research|0 Comments