Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices

Abstract:
The effect of low extracellular Mg2+ concentration ([Mg2+]o) on neuronal activity was studied in rat hippocampal slices. After 20-40 min of perfusion with Mg2+-free medium, when [Mg2+]o declined to approximately 0.1-0.4 mM, spontaneous field potentials developed in the CA1 and CA3 regions, but not in the dentate gyrus. In the CA3 pyramidal cell layer, […]

By |October 14th, 2015|Research|0 Comments

Effect of magnesium chloride and magnesium L-aspartate on seizure threshold in rats under conditions of dietary magnesium deficiency

Abstract:
We studied the effect of Mg-L-aspartate, MgCL2, and their combinations with vitamin B6, magneB6, and MgSO4 on seizure threshold in rats with dietary Mg2+ deficiency. Mg2+ deficiency was followed by a decrease in the threshold dose of corazol (from 79.20 to 49.48 mg/kg), shortening of the latency of the first jerk (by 33.6%, p=0.012), […]

By |October 14th, 2015|Research|0 Comments

Anticonvulsant effects of magnesium sulfate on hippocampal seizures: therapeutic implications in preeclampsia-eclampsia

Abstract:
OBJECTIVE: The objective of this study was to determine whether magnesium sulfate has central anticonvulsant effects.STUDY DESIGN: In three experiments we investigated the anticonvulsant properties of magnesium sulfate on the hippocampus because of its high density of N-methyl-D-aspartate receptors and link to clinical epilepsy. Seizure activity was elicited in the hippocampus of rats or […]

By |October 14th, 2015|Research|0 Comments

Dietary calcium and phosphorus and seizure susceptibility of magnesium deficient rats

Abstract:
Convulsions are characteristic of magnesium deficiency and hypocalcemia. In this study, weanling rats were fed magnesium deficient diets with varying concentrations of calcium and phosphorus. Diets were either normal (Mg =) or low (Mg-) in magnesium and were either low (Ca- or P-), normal (Ca = or P =) or high (Ca+ or P+) […]

By |October 14th, 2015|Research|0 Comments

Natural approaches to epilepsy

Abstract:
This article reviews research on the use of diet, nutritional supplements, and hormones in the treatment of epilepsy. Potentially beneficial dietary interventions include identifying and treating blood glucose dysregulation, identifying and avoiding allergenic foods, and avoiding suspected triggering agents such as alcohol, aspartame, and monosodium glutamate. The ketogenic diet may be considered for severe, […]

By |October 14th, 2015|Research|0 Comments

Plasma magnesium and calcium levels in children with epilepsy in lagos

Abstract:
BACKGROUND: Magnesium and calcium have been found to have increasing roles in the patho-physiology of epilepsy. Hypomagnesaemia and hypocalcaemia cause hyper-exitability of neurons and have been associated strongly with seizures in adults and children.OBJECTIVES: To determine if hypomagnesaemia or hypocalcaemia is present in Nigerian children with epilepsy and to determine the relationship between serum […]

By |October 14th, 2015|Research|0 Comments

Plasma magnesium in adult Nigerian patients with epilepsy

Abstract:
UNLABELLED: The objective of this study was to determine the relationship between plasma magnesium levels and epilepsy. The study was carried out at the Lagos University Teaching Hospital. Plasma magnesium was estimated using the calmigite dye colorimetric method in 45 adults with epilepsy and 35 healthy controls. Plasma concentrations of calcium, phosphorus and albumin […]

By |October 14th, 2015|Research|0 Comments

Neurological consequences of magnesium deficiency: correlations with epilepsy

Abstract:
1. The plasma calcium and magnesium concentrations of sheep have been manipulated by feeding liquid diets with various calcium and magnesium concentrations. 2. When the magnesium status of the diet was low, both plasma calcium and magnesium concentrations declined, but the decline in calcium was much more rapid and extensive when the content of […]

By |October 14th, 2015|Research|0 Comments

Magnesium deficiency as a cause of acute intractable seizures

Abstract:
Clinical and experimental investigations have shown that magnesium depletion causes a marked irritability of the nervous system, eventually resulting in epileptic seizures. Although magnesium deficiency as a cause of epilepsy is uncommon, its recognition and correction may prove life-saving. Two case reports are presented which emphasize the importance of recognizing hypomagnesaemia in patients with […]

By |October 14th, 2015|Research|0 Comments

Serum magnesium levels in idiopathic epilepsy

Summary:
Magnesium blood levels can be used to predict the frequency of epileptic seizures.

Abstract:
Fifty cases of idiopathic epilepsy and 25 age and sex matched normal healthy controls were studied. There was a significant fall in serum magnesium levels in idiopathic epilepsy on day one and 4 of the seizures (P < 0.01) as [...]

By |October 14th, 2015|Research|1 Comment