Association between copper excess, zinc deficiency, and TP53 mutations in esophageal squamous cell carcinoma from Kashmir Valley, India–a high risk area

Abstract:
Trace element deficiency or excess is implicated in the development or progression in some cancers. Here we report the elevated level of copper and low level of zinc in the plasma of esophageal cancer patients in Kashmir India–a high incidence area. The average level of copper was significantly higher (P < 0.0001) for patients [...]

By |October 16th, 2015|Research|0 Comments

Magnesium influence on nicotine pharmacodependence and smoking

Abstract:
We followed the magnesium effect (Magne B(6)R, Sanofi-Synthelabo) with internal administration in 53 adult neurotic smoking patients (more than 10 cigarettes/day) of both genders admitted into psychiatric hospital. The nicotine dependence was assessed by the Fagerstrom test, initially and after 28 days of magnesium intake. Plasmatic magnesium level was determined before any therapy and […]

By |October 12th, 2015|Research|0 Comments

Zinc involvement in opioid addiction and analgesia–should zinc supplementation be recommended for opioid-treated persons?

Abstract:
INTRODUCTION: Zinc chelators were shown to facilitate some opioid-withdrawal signs in animals. Zinc deficiency, which affects more than 15% the world’s population, is also common among opioid consumers and opioid-treated animals exhibit misbalances of zinc distribution.AIM: The present study focuses on how zinc ions interfere with opioid dependence/addiction and analgesia, trying to preliminary discuss […]

By |October 12th, 2015|Research|0 Comments

Magnesium in drug dependences

Abstract:
Magnesium decreases the intensity of some drug-induced dependences (e.g. opiates, nicotine, cocaine, amphetamine, ethanol, etc.). The main mechanism involved is a decreasing activity of central glutamatergic synapses, especially those involved in the reward system. There are many particularities of action for each drug dependence. Apart from the effects during emerging dependence, magnesium ions administered […]

By |October 12th, 2015|Research|0 Comments

Magnesium treatment in alcoholics: a randomized clinical trial

Abstract:
BACKGROUND: Magnesium (Mg) deficiency is common among alcoholics. Earlier research suggests that Mg treatment may help to normalize elevated enzyme activities and some other clinically relevant parameters among alcoholics but the evidence is weak.METHODS: The effect of Mg was studied in a randomized, parallel group, double-blind trial. The patients were first treated for alcohol […]

By |October 12th, 2015|Research|0 Comments

Magnesium homeostasis and alcohol consumption

Abstract:
Clinical and experimental evidence indicates alcohol consumption as one of the major causes of magnesium loss from several tissues. As a result of this loss, serum magnesium tends to decrease while urinary magnesium excretion increases 2-3 fold. Experimental data confirm that chronic consumption of 6% ethanol in the Lieber De-Carli diet for 3 weeks […]

By |October 12th, 2015|Research|0 Comments