Association between copper excess, zinc deficiency, and TP53 mutations in esophageal squamous cell carcinoma from Kashmir Valley, India–a high risk area

Abstract:
Trace element deficiency or excess is implicated in the development or progression in some cancers. Here we report the elevated level of copper and low level of zinc in the plasma of esophageal cancer patients in Kashmir India–a high incidence area. The average level of copper was significantly higher (P < 0.0001) for patients [...]

By |October 16th, 2015|Research|0 Comments

Copper excess, zinc deficiency, and cognition loss in Alzheimer’s disease

Abstract:
In this special issue about biofactors causing cognitive impairment, we present evidence for and discuss two such biofactors. One is excess copper, causing neuronal toxicity. The other is zinc deficiency, causing neuronal damage. We present evidence that Alzheimer’s disease (AD) has become an epidemic in developed, but not undeveloped, countries and that the epidemic […]

By |October 16th, 2015|Research|0 Comments

Protective role of copper, zinc superoxide dismutase against UVB-induced injury of the human keratinocyte cell line HaCaT

Abstract:
On the basis of our recent observation that copper, zinc-superoxide dismutase and manganese-superoxide dismutase change differently following a single exposure to ultraviolet-B irradiation in the human keratinocyte cell line HaCaT, we have examined the possible role of endogenous copper,zinc-superoxide dismutase or manganese-superoxide dismutase against ultraviolet-B-induced reactive-oxygen- species-mediated keratinocyte injury in vitro. To evaluate the […]

By |October 14th, 2015|Research|0 Comments

Copper in diseases and treatments, and copper-based anticancer strategies

Abstract:
Copper is found in all living organisms and is a crucial trace element in redox chemistry, growth and development. It is important for the function of several enzymes and proteins involved in energy metabolism, respiration, and DNA synthesis, notably cytochrome oxidase, superoxide dismutase, ascorbate oxidase, and tyrosinase. The major functions of copper-biological molecules involve […]

By |October 14th, 2015|Research|0 Comments