Zinc inhibits magnesium-dependent migration of human breast cancer MDA-MB-231 cells on fibronectin

Abstract:
Metastasis is the major cause of breast cancer mortality. The strength of cell adhesion to extracellular matrix is critical to cancer cell migration. Integrins, the primary mediators of cell to extra-cellular matrix adhesion, contain distinct divalent cation-binding sites. Binding of manganese and magnesium is vital to integrin-mediated cancer cell adhesion and migration. We hypothesized […]

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A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients

Abstract:
BACKGROUND: We tested if magnesium would diminish bothersome hot flashes in breast cancer patients.METHODS: Breast cancer patients with at least 14 hot flashes a week received magnesium oxide 400 mg for 4 weeks, escalating to 800 mg if needed. Hot flash score (frequency × severity) at baseline was compared to the end of treatment.RESULTS: Of 29 who enrolled, 25 […]

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Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer?

Abstract:
Breast cancer is the most commonly diagnosed cancer among United States (US) women. Established risk factors explain only about 13% of breast cancer incidence among women in the US. Thus, the cause of most cases of breast cancer remains unknown. In postmenopausal women, serum calcium (Ca) and serum magnesium (Mg) play an important role […]

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Serum levels of metal ions in female patients with breast cancer

Abstract:
BACKGROUND: Breast cancer is the second commonest form of cancer among women. Several studies have been conducted to identify potential risk factors. However, role of trace elements or metals in causing breast cancer has not been studied to great extent.AIMS: To estimate the serum levels of calcium, copper, magnesium, iron, phosphorus and zinc and […]

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