Copper excess, zinc deficiency, and cognition loss in Alzheimer’s disease

Abstract:
In this special issue about biofactors causing cognitive impairment, we present evidence for and discuss two such biofactors. One is excess copper, causing neuronal toxicity. The other is zinc deficiency, causing neuronal damage. We present evidence that Alzheimer’s disease (AD) has become an epidemic in developed, but not undeveloped, countries and that the epidemic […]

By |October 16th, 2015|Research|0 Comments

Calcium in Alzheimer’s disease pathogenesis: too much, too little or in the wrong place?

Abstract:
Our understanding of the molecular genetics and biochemical pathology of Alzheimer’s disease has progressed tremendously in the past decade. The metabolism of amyloid beta-peptide is being unraveled, and specific anti-amyloid therapies are now in clinical trials worldwide. The precise biophysical structure of the amyloid beta-peptide that causes neuronal dysfunction remains under investigation, as does […]

By |October 14th, 2015|Research|0 Comments

Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer’s disease mouse model

Abstract:
Profound synapse loss is one of the major pathological hallmarks associated with Alzheimer’s disease (AD) and might underlie memory impairment. Our previous work demonstrated that the magnesium ion is a critical factor in controlling synapse density/plasticity. Here, we investigated whether elevation of brain magnesium by the use of a recently developed compound, magnesium-l-threonate (MgT), […]

By |October 12th, 2015|Research|0 Comments

Magnesium depletion and pathogenesis of Alzheimer’s disease

Abstract:
Mg depletion, particularly in the hippocampus, appears to represent an important pathogenic factor in Alzheimer’s disease. It is associated with high aluminium incorporation into brain neurones. This type of Mg deficit cannot respond to mere Mg supplementation, but requires correction of the dysregulation inducing this Mg depletion. Further research should seek to control the […]

By |October 12th, 2015|Research|0 Comments

Dementias: the role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer’s disease

Abstract:
Evidence is presented indicating that dementias are associated with a relative insufficiency of Magnesium (Mg) in the brain. Such insufficiency may be attributable to low intake or retention of Mg; high intake of a neurotoxic metal, such as aluminum (Al), which inhibits activity of Mg-requiring enzymes; or impaired transport of Mg and/or enhanced transport […]

By |October 12th, 2015|Research|0 Comments