Effects of magnesium and its mechanism on the incidence of reperfusion arrhythmias following severe ischemia in isolated rat hearts

Abstract:
Magnesium sulfate (Mg) has been widely used for the treatment of ventricular arrhythmias (VF) in patients with coronary artery disease. However, the mechanisms of prevention on the incidence of VF have not been defined. The aim of study was to investigate the role of Mg in the prevention of VF and the mechanism of […]

By |October 18th, 2015|Research|0 Comments

Magnesium supplementation in the prevention of arrhythmias in pediatric patients undergoing surgery for congenital heart defects

Abstract:
BACKGROUND: The efficacy of magnesium in the prevention of arrhythmias in pediatric patients after heart surgery remains unknown. Therefore we prospectively examined the effect of magnesium treatment on the incidence of postoperative arrhythmias in pediatric patients undergoing surgical repair of congenital heart defects.METHODS AND RESULTS: Twenty-eight pediatric patients undergoing heart surgery with cardiopulmonary bypass […]

By |October 18th, 2015|Research|0 Comments

Magnesium treatment of ventricular arrhythmias

Abstract:
The association between marked hypomagnesemia and arrhythmias, particularly those associated with digitalis intoxication, has long been recognized. More recently, acute intervention with magnesium in patients who are not hypomagnesemic has demonstrated arrhythmia suppression in 3 settings: digitalis intoxication, long QT-related arrhythmias and arrhythmias after acute myocardial infarction. Although the electrophysiologic effects of magnesium are […]

By |October 18th, 2015|Research|0 Comments

[Magnesium and arrhythmia]

Abstract:
Experimental and clinical studies have shown the antiarrhythmic activity of magnesium salts and the arrhythmogenic effect of hypomagnesemia. Both are observed mainly but not exclusively during treatment with digitalis. The Mg++ plays an essential role in transmembrane K+ exchange in that a deficit of magnesium leads to a loss of intracellular K+ which cannot […]

By |October 18th, 2015|Research|0 Comments

Effect of acute magnesium administration on the frequency of ventricular arrhythmia in patients with heart failure

Summary:
Giving magnesium to patients with heart failure reduces the frequency of their arrhythmias.

Abstract:
BACKGROUND: There is a high incidence of ventricular arrhythmia and sudden death in patients with heart failure. Unfortunately, currently available antiarrhythmic agents have only limited efficacy and may result in proarrhythmia and hemodynamic deterioration in these patients.METHODS AND RESULTS: We studied […]

By |October 18th, 2015|Research|1 Comment

Magnesium therapy of cardiac arrhythmias in critical-care medicine

Abstract:
A common complication of critically ill patients is cardiac tachyarrhythmia. The role played by magnesium is not well appreciated. Well-documented cases indicated that magnesium may be effective in controlling the rhythm when conventional methods fail. The following tachyarrhythmias respond favorably to magnesium: (1) intractable ventricular tachycardia and fibrillation, whether hypo- or normomagnesemic, (2) torsades […]

By |October 18th, 2015|Research|0 Comments

[Significance of magnesium in cardiac arrhythmias]

Abstract:
Magnesium is of great importance in cardiac arrhythmias. It increases the ventricular threshold for fibrillation. Sinus node refractoriness and conduction in the AV node are both prolonged. Main indications for intravenous application of magnesium are Torsade de pointes tachycardias, digitalis toxicity induced tachyarrhythmias and multifocal atrial tachycardias. Additionally, patients with ventricular arrhythmias due to […]

By |October 18th, 2015|Research|0 Comments

Intravenous magnesium for cardiac arrhythmias: jack of all trades

Abstract:
Intravenous magnesium has been used to prevent and treat many different types of cardiac arrhythmia. It has diverse electrophysiological actions on the conduction system of the heart; including prolonging sinus node recovery time, and reducing automaticity, atrioventricular nodal conduction, antegrade and retrograde conduction over an accessory pathway, and His-ventricular conduction. Intravenous magnesium can also […]

By |October 18th, 2015|Research|0 Comments

Strontium nitrate suppresses chemically-induced sensory irritation in humans

Summary:
Strontium salts strongly reduces stinging, burning, and itching caused by irritating chemicals on the skin.

Abstract:
Skin care products are complex formulations that may cause sensory irritation symptoms, characterized by stinging, burning, and itching. Substances capable of counteracting sensory irritation are of great practical interest. Strontium salts have been demonstrated to inhibit sensory irritation […]

By |October 16th, 2015|Research|1 Comment

Strontium is a potent and selective inhibitor of sensory irritation

Summary:
Strontium salts strongly reduced skin irritation without side-effects, representing a new class of topical anti-inflammatories.

Abstract:
BACKGROUND: Irritant contact dermatitis occurs following topical exposure to many chemicals found in cosmetics, personal care products, drugs, and during occupational exposure. Signs and symptoms may include sensory irritation (sting, burn, and/or itch), erythema, edema, and vesiculation.OBJECTIVE: In […]

By |October 16th, 2015|Research|1 Comment