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Zinc deficiency induces dysregulation of cytokine productions in an experimental colitis of rats

Abstract:
Dextran sulfate sodium (DSS)-induced colitis is an experimental model of ulcerative colitis, although the precise mechanism has not yet been elucidated. We investigate whether Zn deficiency affects the pathogenesis of colitis induced by DSS with a focus on immune responses. Male WKAH/Hkm Slc rats were fed either a Zn-adequate (ZA, 30 mg Zn/kg diet) […]

By |October 14th, 2015|Research|0 Comments

Zinc sulphate solution enema decreases inflammation in experimental colitis in rats

Abstract:
BACKGROUND: It has been reported that zinc sulphate contributes an anti-inflammatory action in many animal models; however, the impact of zinc in colitis remains unclear. The aim of the present study was to examine the role of zinc sulphate in experimental colitis.METHODS: Colitis was induced by 2,4,6-trinitrobenzenesulphonic acid (TNB) in rats. Beginning at the […]

By |October 14th, 2015|Research|0 Comments

Effect of zinc supplementation on intestinal permeability in experimental colitis

Abstract:
Increased small-intestine permeability has been documented in experimental colitis in the rat. Zinc supplementation improves mucosal repair in patients with diarrhea, as well as paracellular permeability in malnourished guinea pigs. In this study, we sought to evaluate the effect of zinc supplementation on small-and large-intestine tight junctions in rats with acute colitis. Rats were […]

By |October 14th, 2015|Research|0 Comments

Hidradenitis suppurativa: the role of deficient cutaneous innate immunity

Abstract:
OBJECTIVE: To evaluate the expression of innate immunity markers at the site of nodules caused by hidradenitis suppurativa (HS).DESIGN: Prospective analysis of 12 patients with HS.SETTING: Unité de Cancéro-Dermatologie, Nantes Hospital, Nantes; Service de Dermatologie, Poitiers Hospital, Poitiers; and Service de Dermatologie, Clinique de Courlancy, Reims, FrancePATIENTS: Twelve patients (Hurley stage I or II) […]

By |October 14th, 2015|Research|0 Comments

Hidradenitis suppurativa and zinc: a new therapeutic approach. A pilot study

Abstract:
BACKGROUND: Hidradenitis suppurativa (Verneuil’s disease) is a chronic suppurative dermatosis involving apocrine glands with a severe impact on the quality of life, which is enhanced by the fact that the drugs usually prescribed are poorly effective.OBJECTIVE: We discuss a new therapeutic approach based on zinc salts.METHODS: We performed a pilot study on 22 patients, […]

By |October 14th, 2015|Research|0 Comments

Innovative uses for zinc in dermatology

Abstract:
Severe zinc deficiency states, such as acrodermatitis enteropathica, are associated with a variety of skin manifestations, such as perioral, acral, and perineal dermatitis. These syndromes can be reversed with systemic zinc repletion. In addition to skin pathologies that are clearly zinc-dependent, many dermatologic conditions (eg, dandruff, acne, and diaper rash) have been associated and […]

By |October 14th, 2015|Research|0 Comments

Evidence supporting zinc as an important antioxidant for skin

Abstract:
Antioxidants play a critical role in keeping skin healthy. The antioxidant benefits of vitamin C and E are well known, but the importance of the trace mineral, zinc, has been overlooked. This article reviews the evidence supporting zinc’s antioxidant role in protecting against free radical-induced oxidative damage. Zinc protects against UV radiation, enhances wound […]

By |October 14th, 2015|Research|0 Comments

Zinc and the skin

Abstract:
Zinc is an essential trace element integrally involved in a wide range of metabolic processes required for tissue growth and repair as well as being necessary for maintaining host defences. Zinc deficiency can occur from lack of adequate dietary intake, decreased intestinal absorption, and increased losses in the gastrointestinal tract, urine, and sweat. The […]

By |October 14th, 2015|Research|0 Comments

Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials

Abstract:
BACKGROUND: Zinc deficiency is prevalent in children in developing countries. Supplemental zinc provides therapeutic benefits in diarrhea.OBJECTIVE: We sought to measure the effect of supplemental zinc given with oral rehydration therapy during recovery from acute or persistent diarrhea.DESIGN: We conducted pooled analyses including all available published and unpublished randomized controlled trials of the effects […]

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Clinical manifestations of zinc deficiency

Abstract:
The essentiality of zinc for humans was recognized in the early 1960s. The causes of zinc deficiency include malnutrition, alcoholism, malabsorption, extensive burns, chronic debilitating disorders, chronic renal diseases, following uses of certain drugs such as penicillamine for Wilson’s disease and diuretics in some cases, and genetic disorders such as acrodermatitis enteropathica and sickle […]

By |October 14th, 2015|Research|0 Comments