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Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?

Abstract:
The aims of this study were to investigate the relationship between magnesium levels and fibromyalgia symptoms and to determine the effect of magnesium citrate treatment on these symptoms. Sixty premenopausal women diagnosed with fibromyalgia according to the ACR criteria and 20 healthy women whose age and weight matched the premenopausal women were evaluated. Pain […]

By |October 14th, 2015|Research|0 Comments

Chronic fatigue syndrome and mitochondrial dysfunction

Abstract:
This study aims to improve the health of patients suffering from chronic fatigue syndrome (CFS) by interventions based on the biochemistry of the illness, specifically the function of mitochondria in producing ATP (adenosine triphosphate), the energy currency for all body functions, and recycling ADP (adenosine diphosphate) to replenish the ATP supply as needed. Patients […]

By |October 14th, 2015|Research|0 Comments

[A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate]

Abstract:
We have treated a case of chronic fatigue syndrome with atopic diathesis was had suffered general malaise, low grade fever, swelling of the lymph nodes, myalgias and arthralgias for a long time. A 29-year-old female, who had been treated for atopic dermatitis for 5 years, complained of general malaise in May 1990. She was […]

By |October 14th, 2015|Research|0 Comments

Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium

Abstract:
OBJECTIVE: Magnesium deficiency and oxidative stress have both been identified as pathogenic factors in aging and in several age-related diseases. The link between these two factors is unclear in humans although, in experimental animals, severe Mg deficiency has been shown to lead to increased oxidative stress.METHODS: The relationship between Mg body stores, dietary intakes […]

By |October 14th, 2015|Research|0 Comments

Multivitamin mineral supplementation in patients with chronic fatigue syndrome

Abstract:
BACKGROUND: Chronic fatigue syndrome (CFS) is characterized by medically unexplained persistent or reoccurring fatigue lasting at least 6 months. CFS has a multifactorial pathogenesis in which oxidative stress (OS) plays a prominent role. Treatment is with a vitamin and mineral supplement, but this therapeutic option so far has not been properly researched.MATERIAL AND METHODS: […]

By |October 14th, 2015|Research|0 Comments

Red blood cell magnesium and chronic fatigue syndrome

Abstract:
The hypotheses that patients with chronic fatigue syndrome (CFS) have low red blood cell magnesium and that magnesium treatment would improve the wellbeing of such patients were tested in a case-control study and a randomised, double-blind, placebo-controlled trial, respectively. In the case-control study, 20 patients with CFS had lower red cell magnesium concentrations than […]

By |October 14th, 2015|Research|0 Comments

Magnesium and cancer: a dangerous liason

Abstract:
A complex relationship links magnesium and cancer. The aim of this review is to revisit current knowledge concerning the contribution of magnesium to tumorigenesis, from transformed cells to animal models, and ending with data from human studies. Cultured neoplastic cells tend to accumulate magnesium. High intracellular levels of the cation seem to confer a […]

By |October 14th, 2015|Research|0 Comments

Magnesium intake in relation to risk of colorectal cancer in women

Abstract:
CONTEXT: Animal studies have suggested that dietary magnesium may play a role in the prevention of colorectal cancer, but data in humans are lacking.OBJECTIVE: To evaluate the hypothesis that a high magnesium intake reduces the risk of colorectal cancer in women.DESIGN, SETTING, AND PARTICIPANTS: The Swedish Mammography Cohort, a population-based prospective cohort of 61,433 […]

By |October 14th, 2015|Research|0 Comments

Magnesium deficiency inhibits primary tumor growth but favors metastasis in mice

Abstract:
The results of several experimental and epidemiological studies have shown an inverse correlation between Mg status and the risk of some cancers. However, relationship between magnesium and cancer is complex. The aim of our work was to examine the precise effect of Mg deficiency on transplantable mouse tumor growth and metastasis. The results obtained […]

By |October 14th, 2015|Research|0 Comments

Dietary magnesium intake and risk of cancer: a meta-analysis of epidemiologic studies

Abstract:
The aim of this study was to investigate the association between dietary magnesium and the risk of overall cancer using a meta-analysis. We searched PubMed, SCOPUS, and the Cochrane Review through November 2012. All the articles searched were independently reviewed by 3 authors based on predetermined selection criterion. A total of 13 epidemiologic studies, […]

By |October 14th, 2015|Research|0 Comments

Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality

Abstract:
BACKGROUND: Experimental data suggest that zinc, copper, and magnesium are involved in carcinogenesis and atherogenesis. Few longitudinal studies have related these minerals to cancer or cardiovascular disease mortality in a population.METHODS: Data from the Paris Prospective Study 2, a cohort of 4035 men age 30-60 years at baseline, were used to assess the association […]

By |October 14th, 2015|Research|0 Comments

Nonlinear association between magnesium intake and the risk of colorectal cancer

Abstract:
OBJECTIVES: The association between dietary magnesium intake and the risk of colorectal cancer has been examined by many prospective studies, but remains controversial because of inconsistent results. We aimed to carry out a meta-analysis to investigate this.MATERIALS AND METHODS: We assessed this association with categorical and dose-response meta-analysis of data from prospective cohort studies. […]

By |October 14th, 2015|Research|0 Comments

High dietary intake of magnesium may decrease risk of colorectal cancer in Japanese men

Abstract:
Magnesium maintains genomic stability and is an essential cofactor for DNA synthesis and repair. Magnesium intake has been reported to be inversely associated with colorectal cancer (CRC) risk in Western populations. This study examined the association between dietary intake of magnesium and CRC risk in Japanese men and women aged 45-74 y. Data from […]

By |October 14th, 2015|Research|0 Comments

Magnesium intake and risk of colorectal cancer: a meta-analysis of prospective studies

Abstract:
Epidemiologic studies have suggested that magnesium intake may be associated with a decreased risk of colorectal cancer (CRC), but the findings have been inconsistent. We aimed to assess this association by conducting a meta-analysis of prospective studies. We performed a literature search on PubMed database through July 2012 to identify prospective studies of magnesium […]

By |October 14th, 2015|Research|0 Comments

Effects of magnesium supplementation in testicular cancer patients receiving cis-platin: a randomised trial

Abstract:
The concentration of magnesium in serum has been shown to fall to potentially dangerously low levels after several courses of treatment with cis-diamminedichloroplatinum II (cis-platin). The aims of this study were to examine the effects of magnesium supplementation on predicted outcome of treatment, rate of response to treatment and toxicity of treatment. Sixteen patients […]

By |October 14th, 2015|Research|0 Comments

Blood magnesium, and the interaction with calcium, on the risk of high-grade prostate cancer

Abstract:
BACKGROUND: Ionized calcium (Ca) and magnesium (Mg) compete as essential messengers to regulate cell proliferation and inflammation. We hypothesized that inadequate Mg levels, perhaps relative to Ca levels (e.g. a high Ca/Mg ratio) are associated with greater prostate cancer risk.STUDY DESIGN: In this biomarker sub-study of the Nashville Men’s Health Study (NMHS), we included […]

By |October 14th, 2015|Research|0 Comments

Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance

Abstract:
Celiac disease, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North America and Europe, where an estimated 5% of the population now suffers from it. Symptoms include nausea, diarrhea, skin rashes, macrocytic anemia and depression. It is a multifactorial disease associated with numerous nutritional deficiencies as well as reproductive […]

By |October 13th, 2015|Research|0 Comments

[Reasons for magnesium deficiency in children with coeliac disease]

Abstract:
UNLABELLED: Magnesium (Mg) deficiency is often noted in patients with coeliac disease (CD). The aim of the study was the analysis of the reasons of this deficiency in children with CD, diagnosed according to ESPGAN criteria.MATERIAL: The study was performed on 41 patients aged 6-18 years adhering to strict gluten-free diet GFD(+) for mean […]

By |October 13th, 2015|Research|0 Comments

Magnesium status in children and adolescents with coeliac disease without malabsorption symptoms

Abstract:
BACKGROUND & AIMS: Magnesium deficiency has been reported in coeliac disease (CD) with clinical symptoms. The aim of this study was to evaluate magnesium status in CD without malabsorption symptoms in patients aged 5-18 years. In the study participated 41 coeliac patients on a gluten-free diet (GFD) for a mean 11 years with IgAEmA […]

By |October 13th, 2015|Research|0 Comments

Appropriate nutrient supplementation in celiac disease

Abstract:
Reduced levels of iron, folate, vitamin B12, vitamin D, zinc, and magnesium are common in untreated celiac disease (CD) patients probably due to loss of brush border proteins and enzymes needed for the absorption of these nutrients. In the majority of patients, removal of gluten from the diet leads to histological recovery and normalization […]

By |October 13th, 2015|Research|0 Comments

Zinc inhibits magnesium-dependent migration of human breast cancer MDA-MB-231 cells on fibronectin

Abstract:
Metastasis is the major cause of breast cancer mortality. The strength of cell adhesion to extracellular matrix is critical to cancer cell migration. Integrins, the primary mediators of cell to extra-cellular matrix adhesion, contain distinct divalent cation-binding sites. Binding of manganese and magnesium is vital to integrin-mediated cancer cell adhesion and migration. We hypothesized […]

By |October 13th, 2015|Research|0 Comments

Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer?

Abstract:
Breast cancer is the most commonly diagnosed cancer among United States (US) women. Established risk factors explain only about 13% of breast cancer incidence among women in the US. Thus, the cause of most cases of breast cancer remains unknown. In postmenopausal women, serum calcium (Ca) and serum magnesium (Mg) play an important role […]

By |October 13th, 2015|Research|0 Comments

A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients

Abstract:
BACKGROUND: We tested if magnesium would diminish bothersome hot flashes in breast cancer patients.METHODS: Breast cancer patients with at least 14 hot flashes a week received magnesium oxide 400 mg for 4 weeks, escalating to 800 mg if needed. Hot flash score (frequency × severity) at baseline was compared to the end of treatment.RESULTS: Of 29 who enrolled, 25 […]

By |October 13th, 2015|Research|0 Comments

Serum levels of metal ions in female patients with breast cancer

Abstract:
BACKGROUND: Breast cancer is the second commonest form of cancer among women. Several studies have been conducted to identify potential risk factors. However, role of trace elements or metals in causing breast cancer has not been studied to great extent.AIMS: To estimate the serum levels of calcium, copper, magnesium, iron, phosphorus and zinc and […]

By |October 13th, 2015|Research|0 Comments

Bipolar disorder and complementary medicine: current evidence, safety issues, and clinical considerations

Abstract:
BACKGROUND: Bipolar disorder (BD) is a debilitating syndrome that is often undiagnosed and undertreated. Population surveys show that persons with BD often self-medicate with complementary and alternative medicine (CAM) or integrative therapies in spite of limited research evidence supporting their use. To date, no review has focused specifically on nonconventional treatments of BD.OBJECTIVES: The […]

By |October 13th, 2015|Research|0 Comments

Nutrient-based therapies for bipolar disorder: a systematic review

Abstract:
BACKGROUND: Pharmacotherapy is the first line of treatment for bipolar disorder, but many patients continue to experience persistent subthreshold symptoms. Alternative adjunct treatments, including nutritional therapies, may have the potential to alleviate residual symptoms and improve the outcomes of standard pharmacotherapy. The aim of this paper is to critically review the current clinical evidence […]

By |October 13th, 2015|Research|0 Comments

A pilot study of magnesium aspartate hydrochloride (Magnesiocard) as a mood stabilizer for rapid cycling bipolar affective disorder patients

Abstract:
1. Nine severe rapid cycling manic-depressive patients were treated with a magnesium preparation, Magnesiocard 40 mEq/day in an open label study for a period up to 32 weeks. 2. Magnesiocard was found to have clinical results at least equivalent to those of lithium in about 50% of these patients. These results were obtained in […]

By |October 13th, 2015|Research|0 Comments

Treatment of severe mania with intravenous magnesium sulphate as a supplementary therapy

Abstract:
Ten patients with severe, therapy-resistant manic agitation received magnesium sulphate infusions with a continuous magnesium (Mg) flow of approximately 200 mg/h (4353+/-836 mg/day; daily monitored Mg plasma level: 2.44+/-0.34 mmol/l) for periods ranging from 7 to 23 days. Concomitant psychotropic treatment consisted of lithium (n = 10), haloperidol (n = 5) and clonazepam (n […]

By |October 13th, 2015|Research|0 Comments

Adjunctive nutraceuticals with standard pharmacotherapies in bipolar disorder: a systematic review of clinical trials

Abstract:
OBJECTIVE:   Studies using augmentation of pharmacotherapies with nutraceuticals in bipolar disorder (BD) have been conducted and preliminary evidence in many cases appears positive. To date, however, no specialized systematic review of this area has been conducted. We present the first systematic review of clinical trials using nutrient-based nutraceuticals in combination with standard pharmacotherapies […]

By |October 13th, 2015|Research|0 Comments

Magnesium attenuates post-traumatic depression/anxiety following diffuse traumatic brain injury in rats

Abstract:
OBJECTIVE: Magnesium (Mg) declines after traumatic brain injury (TBI), a decline believed associated with ensuing neuronal cell death and subsequent functional impairment. While Mg’s effects on motor and cognitive deficits following TBI have been well studied, few studies have addressed post-traumatic depression as an outcome parameter, despite its being a major clinical problem with […]

By |October 12th, 2015|Research|0 Comments

Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment

Abstract:
Preclinical and some clinical studies suggest a relationship between perturbation in magnesium (Mg(2+)) homeostasis and pathological anxiety, although the underlying mechanisms remain largely unknown. Since there is evidence that Mg(2+) modulates the hypothalamic-pituitary adrenal (HPA) axis, we tested whether enhanced anxiety-like behaviour can be reliably elicited by dietary Mg(2+) deficiency and whether Mg(2+) deficiency […]

By |October 12th, 2015|Research|0 Comments

Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study

Abstract:
OBJECTIVE: Systemic inflammation is associated with both the dietary intake of magnesium, and depression. Limited experimental and clinical data suggest an association between magnesium and depression. Thus, there are reasons to consider dietary magnesium as a variable of interest in depressive disorders. The aim of the present study was to examine the association between […]

By |October 12th, 2015|Research|0 Comments

Rapid recovery from major depression using magnesium treatment

Abstract:
Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism, anhedonia and sadness where these symptoms severely disrupt and adversely affect the person’s life, sometimes to such an extent that suicide is attempted or results. Antidepressant drugs are not always effective and some have been accused of causing […]

By |October 12th, 2015|Research|0 Comments

Magnesium in depression

Abstract:
Magnesium is one of the most essential mineral in the human body, connected with brain biochemistry and the fluidity of neuronal membrane. A variety of neuromuscular and psychiatric symptoms, including different types of depression, was observed in magnesium deficiency. Plasma/serum magnesium levels do not seem to be the appropriate indicators of depressive disorders, since […]

By |October 12th, 2015|Research|0 Comments

Effects of dietary magnesium supplementation on diurnal variations of blood pressure and plasma Na+, K(+)-ATPase activity in essential hypertension

Abstract:
To evaluate the antihypertensive and hormonal effects of oral magnesium supplementation, 17 inpatients with untreated, uncomplicated mild-to-moderate essential hypertension (EH) and 8 age-matched normotensive controls (controls) were given MgO orally 3 times a day at a daily dose of 1.0 g (0.6 g per day as Mg) for a period of 2 weeks. Supplementation […]

By |October 12th, 2015|Research|0 Comments

Oral magnesium supplementation reduces ambulatory blood pressure in patients with mild hypertension

Abstract:
BACKGROUND: Accumulating evidence implicates a role of Mg(2+) in the pathophysiology of essential hypertension. Previous studies evaluating the antihypertensive efficacy of Mg(2+) supplementation gave contradictory results. This study aimed to investigate the effect of oral Mg(2+) supplementation on 24-h blood pressure (BP) and intracellular ion status in patients with mild hypertension.METHODS: A total of […]

By |October 12th, 2015|Research|0 Comments

[Magnesium and hypertension]

Abstract:
Magnesium status has a direct effect upon the relaxation capability of vascular smooth muscle cells and the regulation of the cellular placement of other cations important to blood pressure – cellular sodium:potassium (Na:K) ratio and intracellular calcium (iCa(2+)). As a result, nutritional magnesium has both direct and indirect impacts on the regulation of blood […]

By |October 12th, 2015|Research|0 Comments

Magnesium intake and risk of type 2 diabetes in men and women

Abstract:
OBJECTIVE: To examine the association between magnesium intake and risk of type 2 diabetes.RESEARCH DESIGN AND METHODS: We followed 85,060 women and 42,872 men who had no history of diabetes, cardiovascular disease, or cancer at baseline. Magnesium intake was evaluated using a validated food frequency questionnaire every 2-4 years. After 18 years of follow-up […]

By |October 12th, 2015|Research|0 Comments

Magnesium influence on nicotine pharmacodependence and smoking

Abstract:
We followed the magnesium effect (Magne B(6)R, Sanofi-Synthelabo) with internal administration in 53 adult neurotic smoking patients (more than 10 cigarettes/day) of both genders admitted into psychiatric hospital. The nicotine dependence was assessed by the Fagerstrom test, initially and after 28 days of magnesium intake. Plasmatic magnesium level was determined before any therapy and […]

By |October 12th, 2015|Research|0 Comments

Zinc involvement in opioid addiction and analgesia–should zinc supplementation be recommended for opioid-treated persons?

Abstract:
INTRODUCTION: Zinc chelators were shown to facilitate some opioid-withdrawal signs in animals. Zinc deficiency, which affects more than 15% the world’s population, is also common among opioid consumers and opioid-treated animals exhibit misbalances of zinc distribution.AIM: The present study focuses on how zinc ions interfere with opioid dependence/addiction and analgesia, trying to preliminary discuss […]

By |October 12th, 2015|Research|0 Comments

Magnesium in drug dependences

Abstract:
Magnesium decreases the intensity of some drug-induced dependences (e.g. opiates, nicotine, cocaine, amphetamine, ethanol, etc.). The main mechanism involved is a decreasing activity of central glutamatergic synapses, especially those involved in the reward system. There are many particularities of action for each drug dependence. Apart from the effects during emerging dependence, magnesium ions administered […]

By |October 12th, 2015|Research|0 Comments

Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer’s disease mouse model

Abstract:
Profound synapse loss is one of the major pathological hallmarks associated with Alzheimer’s disease (AD) and might underlie memory impairment. Our previous work demonstrated that the magnesium ion is a critical factor in controlling synapse density/plasticity. Here, we investigated whether elevation of brain magnesium by the use of a recently developed compound, magnesium-l-threonate (MgT), […]

By |October 12th, 2015|Research|0 Comments

Dementias: the role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer’s disease

Abstract:
Evidence is presented indicating that dementias are associated with a relative insufficiency of Magnesium (Mg) in the brain. Such insufficiency may be attributable to low intake or retention of Mg; high intake of a neurotoxic metal, such as aluminum (Al), which inhibits activity of Mg-requiring enzymes; or impaired transport of Mg and/or enhanced transport […]

By |October 12th, 2015|Research|0 Comments

Magnesium depletion and pathogenesis of Alzheimer’s disease

Abstract:
Mg depletion, particularly in the hippocampus, appears to represent an important pathogenic factor in Alzheimer’s disease. It is associated with high aluminium incorporation into brain neurones. This type of Mg deficit cannot respond to mere Mg supplementation, but requires correction of the dysregulation inducing this Mg depletion. Further research should seek to control the […]

By |October 12th, 2015|Research|0 Comments

Oral magnesium supplementation in asthmatic children: a double-blind randomized placebo-controlled trial

Abstract:
OBJECTIVE: To investigate the long-term effect of oral magnesium supplementation on clinical symptoms, bronchial reactivity, lung function and allergen-induced skin responses in children and adolescents with moderate persistent asthma.DESIGN: A double-blind randomized parallel placebo-controlled study.SETTING AND SUBJECTS: The patients were recruited from the Pediatric Outpatient Clinic, Division of Pulmonology, Allergy and Immunology, and followed […]

By |October 12th, 2015|Research|0 Comments

Intravenous magnesium therapy for moderate to severe pediatric asthma: results of a randomized, placebo-controlled trial

Abstract:
OBJECTIVE: To evaluate the efficacy of intravenous magnesium (IVMg) therapy for moderate to severe asthma exacerbations in pediatric patients.DESIGN: Randomized, double-blind, placebo-controlled, clinical trial.SETTING: Urban pediatric emergency department.PARTICIPANTS: Thirty-one patients aged 6 to 18 years who were being treated for an acute asthma exacerbation with peak expiratory flow rate (PEFR) less than 60% of […]

By |October 12th, 2015|Research|0 Comments

Magnesium sulfate for treating exacerbations of acute asthma in the emergency department

Abstract:
BACKGROUND: Treatment of acute asthma is based on rapid reversal of bronchospasm and arresting airway inflammation. There is some evidence that intravenous magnesium can provide additional bronchodilation when given in conjunction with standard bronchodilating agents and corticosteroids. No systematic review of this literature has been completed on this topic.OBJECTIVES: To examine the effect of […]

By |October 12th, 2015|Research|0 Comments

Effect of oral magnesium supplementation on measures of airway resistance and subjective assessment of asthma control and quality of life in men and women with mild to moderate asthma: a randomized placebo controlled trial

Abstract:
BACKGROUND: Epidemiological data shows low dietary magnesium(Mg) may be related to incidence and progression of asthma.OBJECTIVE: To determine if long term(6.5 month) treatment with oral Mg would improve asthma control and increase serum measures of Mg status in men and women with mild-to-moderate asthma.SUBJECTS: 55 males and females aged 21 to 55 years with […]

By |October 12th, 2015|Research|0 Comments

Magnesium for treatment of asthma in children

Abstract:
QUESTION: Magnesium is considered adjuvant therapy for moderate to severe asthma exacerbations in adults, but can it be used to treat children?ANSWER: Magnesium seems to be beneficial in the treatment of moderate to severe asthma in children. It is a safe drug to administer, but there have been minor side effects reported, such as […]

By |October 12th, 2015|Research|0 Comments

Magnesium treatment in alcoholics: a randomized clinical trial

Abstract:
BACKGROUND: Magnesium (Mg) deficiency is common among alcoholics. Earlier research suggests that Mg treatment may help to normalize elevated enzyme activities and some other clinically relevant parameters among alcoholics but the evidence is weak.METHODS: The effect of Mg was studied in a randomized, parallel group, double-blind trial. The patients were first treated for alcohol […]

By |October 12th, 2015|Research|0 Comments