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Strontium chloride: can it be a new treatment option for ulcerative colitis?

Summary:
Strontium salts are as effective as prednisone for treating ulcerative colitis, but without the side-effects!

Abstract:
BACKGROUND/AIMS: Patients with ulcerative colitis still need effective therapy without major side effects. It has been found that strontium can suppress NFκB activation induced by TNF-α. This opens a gate to a new anti-TNF agent which is cheap […]

By |October 16th, 2015|Research|1 Comment

Efficacy of strontium chloride in dental hypersensitivity

Abstract:
Controlled stimuli were used to evaluate a commercially available dentifrice containing 10% strontium chloride hexahydrate for efficacy in alleviating the symptoms of uncomplicated dentinal hypersensitivity. Sixty-one subjects with hypersensitivity were included in the 12-week, double-blind, parallel, comparative (placebo) study. Levels of hypersensitivity in affected teeth were assessed by three methods: thermally controlled cold air […]

By |October 16th, 2015|Research|0 Comments

Controlled clinical evaluation of a 10% strontium chloride dentifrice in treatment of dentin hypersensitivity following periodontal surgery

Abstract:
Sixty adult patients were examined for dentin hypersensitivity prior to periodontal surgery. Stimuli used included mechanical, cold water and compressed air blasts. A subjective assessment of the degree of hypersensitivity for each stimulus was recorded. This presurgical examination revealed 249 hypersensitive areas among 60 subjects. Following surgery there was over a 100% increase in […]

By |October 16th, 2015|Research|0 Comments

Association between copper excess, zinc deficiency, and TP53 mutations in esophageal squamous cell carcinoma from Kashmir Valley, India–a high risk area

Abstract:
Trace element deficiency or excess is implicated in the development or progression in some cancers. Here we report the elevated level of copper and low level of zinc in the plasma of esophageal cancer patients in Kashmir India–a high incidence area. The average level of copper was significantly higher (P < 0.0001) for patients [...]

By |October 16th, 2015|Research|0 Comments

Copper excess, zinc deficiency, and cognition loss in Alzheimer’s disease

Abstract:
In this special issue about biofactors causing cognitive impairment, we present evidence for and discuss two such biofactors. One is excess copper, causing neuronal toxicity. The other is zinc deficiency, causing neuronal damage. We present evidence that Alzheimer’s disease (AD) has become an epidemic in developed, but not undeveloped, countries and that the epidemic […]

By |October 16th, 2015|Research|0 Comments

Selenium in cancer prevention: a review of the evidence and mechanism of action

Abstract:
Se is an unusual trace element in having its own codon in mRNA that specifies its insertion into selenoproteins as selenocysteine (SeCys), by means of a mechanism requiring a large SeCys-insertion complex. This exacting insertion machinery for selenoprotein production has implications for the Se requirements for cancer prevention. If Se may protect against cancer, […]

By |October 16th, 2015|Research|0 Comments

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

Abstract:
OBJECTIVE: To determine whether a nutritional supplement of selenium will decrease the incidence of cancer.DESIGN: A multicenter, double-blind, randomized, placebo-controlled cancer prevention trial.SETTING: Seven dermatology clinics in the eastern United States.PATIENTS: A total of 1312 patients (mean age, 63 years; range, 18-80 years) with a history of basal cell or squamous cell carcinomas of […]

By |October 16th, 2015|Research|0 Comments

Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the action of selenium

Abstract:
We reported previously that garlic cultivated with selenite fertilization showed powerful chemopreventive activity in the rat dimethylbenz[a]anthracene (DMBA)-induced mammary tumor model (Carcinogenesis 15, 573-576, 1994). In order to ascertain that the efficacy of the high-selenium garlic in cancer protection is primarily dependent on the action of selenium we compared the effects of two batches […]

By |October 16th, 2015|Research|0 Comments

Protective role of copper, zinc superoxide dismutase against UVB-induced injury of the human keratinocyte cell line HaCaT

Abstract:
On the basis of our recent observation that copper, zinc-superoxide dismutase and manganese-superoxide dismutase change differently following a single exposure to ultraviolet-B irradiation in the human keratinocyte cell line HaCaT, we have examined the possible role of endogenous copper,zinc-superoxide dismutase or manganese-superoxide dismutase against ultraviolet-B-induced reactive-oxygen- species-mediated keratinocyte injury in vitro. To evaluate the […]

By |October 14th, 2015|Research|0 Comments

Copper in diseases and treatments, and copper-based anticancer strategies

Abstract:
Copper is found in all living organisms and is a crucial trace element in redox chemistry, growth and development. It is important for the function of several enzymes and proteins involved in energy metabolism, respiration, and DNA synthesis, notably cytochrome oxidase, superoxide dismutase, ascorbate oxidase, and tyrosinase. The major functions of copper-biological molecules involve […]

By |October 14th, 2015|Research|0 Comments